Generate tailored AI agent instruction files via AgentRC instructions command. Produces .github/copilot-instructions.md (default, recommended for Copilot in VS Code) plus optional per-area .instructions.md files with applyTo globs for monorepos. Use after running /acreadiness-assess to close gaps in the AI Tooling pillar.
All Claude skills
1450 open-source skills for Claude Code and compatible agents, ranked by quality and popularity. Showing 241–300.
Help the user pick, write, or apply an AgentRC policy. Policies customise readiness scoring by disabling irrelevant checks, overriding impact/level, setting pass-rate thresholds, or chaining org baselines with team overrides. Use when the user asks about strict mode, AI-only scoring, custom weights, CI gating, or wants org-wide standardisation.
Use this skill when the user shares ad campaign performance data and asks what to cut, scale, or test. Trigger for prompts like "analyze my ad campaigns", "where am I wasting ad spend", "reallocate my ad budget", "which ads are actually working", or "ROAS analysis". Do not trigger for campaign planning or creative generation without performance data.
Write, debug, and optimize Adobe Illustrator automation scripts using ExtendScript (JavaScript/JSX). Use when creating or modifying scripts that manipulate documents, layers, paths, text frames, colors, symbols, artboards, or any Illustrator DOM objects. Covers the complete JavaScript object model, coordinate system, measurement units, export workflows, and scripting best practices.
Patterns and techniques for adding governance, safety, and trust controls to AI agent systems. Use this skill when: - Building AI agents that call external tools (APIs, databases, file systems) - Implementing policy-based access controls for agent tool usage - Adding semantic intent classification to detect dangerous prompts - Creating trust scoring systems for multi-agent workflows - Building audit trails for agent actions and decisions - Enforcing rate limits, content filters, or tool restrictions on agents - Working with any agent framework (PydanticAI, CrewAI, OpenAI Agents, LangChain, AutoGen)
Check any AI agent codebase against the OWASP Agentic Security Initiative (ASI) Top 10 risks. Use this skill when: - Evaluating an agent system's security posture before production deployment - Running a compliance check against OWASP ASI 2026 standards - Mapping existing security controls to the 10 agentic risks - Generating a compliance report for security review or audit - Comparing agent framework security features against the standard - Any request like "is my agent OWASP compliant?", "check ASI compliance", or "agentic security audit"
Find, evaluate, and assemble the smallest compatible set of AI Agent Skills for an end-to-end natural-language goal. Use when a user wants Skills for a multi-step workflow, asks which Skills fit a project, needs an installed-Skill audit or conflict check, has low Skill recall, wants indirect helpers such as humanizers or compliance checks, or wants a project-specific Skill Stack with controlled installation. Search local Skills, registries, GitHub, and OpenCLI; compare adoption, verified fit, safety, and overlap. Do not use for locating one known or common Skill; use the generic find-skills workflow.
Verify supply chain integrity for AI agent plugins, tools, and dependencies. Use this skill when: - Generating SHA-256 integrity manifests for agent plugins or tool packages - Verifying that installed plugins match their published manifests - Detecting tampered, modified, or untracked files in agent tool directories - Auditing dependency pinning and version policies for agent components - Building provenance chains for agent plugin promotion (dev → staging → production) - Any request like "verify plugin integrity", "generate manifest", "check supply chain", or "sign this plugin"
Patterns and techniques for evaluating and improving AI agent outputs. Use this skill when: - Implementing self-critique and reflection loops - Building evaluator-optimizer pipelines for quality-critical generation - Creating test-driven code refinement workflows - Designing rubric-based or LLM-as-judge evaluation systems - Adding iterative improvement to agent outputs (code, reports, analysis) - Measuring and improving agent response quality
Comprehensive AI prompt engineering safety review and improvement prompt. Analyzes prompts for safety, bias, security vulnerabilities, and effectiveness while providing detailed improvement recommendations with extensive frameworks, testing methodologies, and educational content.
Make any repo AI-ready — analyzes your codebase and generates AGENTS.md, copilot-instructions.md, CI workflows, issue templates, and more. Mines your PR review patterns and creates files customized to your stack. USE THIS SKILL when the user asks to "make this repo ai-ready", "set up AI config", or "prepare this repo for AI contributions".
Bootstrap and run a lightweight multi-agent development team. Use when starting or adopting a project, planning work, coordinating implementation and optional QA, brainstorming with distinct perspectives, or preserving context across sessions.
Stop Codex, GitHub Copilot, Claude Code, and Cursor from shipping generic UI. Use UIZZE’s public catalogue of 800,000+ real web and iOS screens to extract product-specific design decisions and enforce a hard finish gate for web and iOS interfaces.
Serves as a reviewer of the codebase with instructions on looking for Apple App Store optimizations or rejection reasons.
Comprehensive project architecture blueprint generator that analyzes codebases to create detailed architectural documentation. Automatically detects technology stacks and architectural patterns, generates visual diagrams, documents implementation patterns, and provides extensible blueprints for maintaining architectural consistency and guiding new development.
Design and implement Arduino integration with Azure IoT Hub and IoT Edge, including secure provisioning, resilient telemetry, command handling, and production guardrails.
Creates, reads, updates, and deletes Arize AI integrations that store LLM provider credentials used by evaluators and other Arize features. Supports any LLM provider (e.g. OpenAI, Anthropic, Azure OpenAI, AWS Bedrock, Vertex AI, Gemini, NVIDIA NIM). Use when the user mentions AI integration, LLM provider credentials, create integration, list integrations, update credentials, delete integration, or connecting an LLM provider to Arize.
Creates and manages annotation configs (categorical, continuous, freeform label schemas) and annotation queues (human review workflows) on Arize. Applies human annotations to project spans via the Python SDK. Use when the user mentions annotation config, annotation queue, label schema, human feedback, bulk annotate spans, update_annotations, labeling queue, annotate record, or human review.
Creates, manages, and queries Arize datasets and examples. Covers dataset CRUD, appending examples, exporting data, and file-based dataset creation using the ax CLI. Use when the user needs test data, evaluation examples, or mentions create dataset, list datasets, export dataset, append examples, dataset version, golden dataset, or test set.
Handles LLM-as-judge evaluation workflows on Arize including creating/updating evaluators, running evaluations on spans or experiments, managing tasks, trigger-run operations, column mapping, and continuous monitoring. Use when the user mentions create evaluator, LLM judge, hallucination, faithfulness, correctness, relevance, run eval, score spans, score experiment, trigger-run, column mapping, continuous monitoring, or improve evaluator prompt.
Creates, runs, and analyzes Arize experiments for evaluating and comparing model performance. Covers experiment CRUD, exporting runs, comparing results, and evaluation workflows using the ax CLI. Use when the user mentions create experiment, run experiment, compare models, model performance, evaluate AI, experiment results, benchmark, A/B test models, or measure accuracy.
Adds Arize AX tracing to an LLM application for the first time. Follows a two-phase agent-assisted flow to analyze the codebase then implement instrumentation after user confirmation. Use when the user wants to instrument their app, add tracing from scratch, set up LLM observability, integrate OpenTelemetry or openinference, or get started with Arize tracing.
Generates deep links to the Arize UI for traces, spans, sessions, datasets, labeling queues, evaluators, and annotation configs. Produces clickable URLs for sharing Arize resources with team members. Use when the user wants to link to or open a trace, span, session, dataset, evaluator, or annotation config in the Arize UI.
Optimizes, improves, and debugs LLM prompts using production trace data, evaluations, and annotations. Extracts prompts from spans, gathers performance signal, and runs a data-driven optimization loop using the ax CLI. Use when the user mentions optimize prompt, improve prompt, make AI respond better, improve output quality, prompt engineering, prompt tuning, or system prompt improvement.
Downloads, exports, and inspects existing Arize traces and spans to understand what an LLM app is doing or debug runtime issues. Covers exporting traces by ID, spans by ID, sessions by ID, and root-cause investigation using the ax CLI. Use when the user wants to look at existing trace data, see what their LLM app is doing, export traces, download spans, investigate errors, or analyze behavior regressions.
Aspire skill covering the Aspire CLI, AppHost orchestration, service discovery, integrations, MCP server, VS Code extension, Dev Containers, GitHub Codespaces, templates, dashboard, and deployment. Use when the user asks to create, run, debug, configure, deploy, or troubleshoot an Aspire distributed application.
Shared audit integrity framework for all AppSec agents — enforces output quality, intellectual honesty, and continuous improvement through anti-rationalization guards, self-critique loops, retry protocols, non-negotiable behaviors, self-reflection quality gates (1-10 scoring, ≥8 threshold), and a self-learning system with lesson/memory governance for security analysis agents.
Analyze a screen recording of a manual process and produce targeted, working automation scripts. Extracts frames and audio narration from video files, reconstructs the step-by-step workflow, and proposes automation at multiple complexity levels using tools already installed on the user machine.
Autonomous iterative experimentation loop for any programming task. Guides the user through defining goals, measurable metrics, and scope constraints, then runs an autonomous loop of code changes, testing, measuring, and keeping/discarding results. Inspired by Karpathy's autoresearch. USE FOR: autonomous improvement, iterative optimization, experiment loop, auto research, performance tuning, automated experimentation, hill climbing, try things automatically, optimize code, run experiments, autonomous coding loop. DO NOT USE FOR: one-shot tasks, simple bug fixes, code review, or tasks without a measurable metric.
Setup and initialization guide for developing AWS CDK (Cloud Development Kit) applications in Python. This skill enables users to configure environment prerequisites, create new CDK projects, manage dependencies, and deploy to AWS.
Reusable investigation patterns for AWS CloudWatch: Logs Insights query templates, alarm-to-deployment correlation, blast-radius narrowing decision tree, and PromQL-style metric query patterns for structured incident triage.
Analyze AWS resources used in the app (IaC files and/or resources in a target account/region) and optimize costs - creating GitHub issues for identified optimizations.
Rewrite text that sounds AI-generated while keeping the writer's facts, meaning, and voice. Use when editing or reviewing prose for inflated claims, sales language, vague sources, repetitive structure, stock AI words, passive voice, filler, or chatbot artifacts. Based on Wikipedia's "Signs of AI writing."
How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for experimental characterization. Also trigger when code imports `adaptyv`, `adaptyv_sdk`, or `FoundryClient`, or references `foundry-api-public.adaptyvbio.com`.
This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.
Data structure for annotated matrices in single-cell analysis. Use when working with .h5ad files or integrating with the scverse ecosystem. This is the data format skill—for analysis workflows use scanpy; for probabilistic models use scvi-tools; for population-scale queries use cellxgene-census.
Autonomously improve a real artifact (code, training recipe, agent harness, data pipeline, prompt) against an objective and an evaluator, using Hypothesis Tree Refinement (HTR) from the Arbor paper. Use this whenever someone wants to iteratively optimize something over many experiments without overfitting — e.g. "get my model's eval score up", "improve this agent/harness", "tune this pipeline", "beat the baseline on this benchmark", "run a search over approaches and keep the best", "do an MLE-bench / Kaggle-style optimization", or any long-horizon "make this artifact better and don't just memorize the dev set" task. Trigger it even when the user doesn't say "Arbor" or "hypothesis tree" but describes repeated experiment-and-evaluate loops, branching exploration of competing ideas, or worries about a dev/test gap. Runs Claude itself as the coordinator with subagent executors in isolated git worktrees; for the standalone `arbor` CLI tool see references/arbor-upstream.md.
Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
Core Python library for astronomy and astrophysics workflows that need Astropy APIs, including units/quantities, coordinates, FITS I/O, tables, time systems, WCS, and cosmology. Use when implementing or debugging astronomical data analysis code with Astropy.
Observe the user's screen via screenpipe, detect repeated research workflows, match them against existing scientific-agent-skills, and draft new skills (or composition recipes that chain existing ones) for the patterns not yet covered. Use when the user asks to analyze their recent work and propose skills based on what they actually do. Requires the screenpipe daemon (https://github.com/screenpipe/screenpipe) running locally on port 3030 — the skill has no other data source and will refuse to run if screenpipe is unreachable. All detection runs locally; only redacted cluster summaries reach the LLM.
Benchling Python SDK and REST API integration for registry entities, inventory, ELN entries, workflows, Benchling Apps, and Data Warehouse queries. Use when automating lab data with benchling-sdk or the v2 API.
Search scientific papers and retrieve structured experimental data extracted from full-text studies via the BGPT MCP server. Returns 25+ fields per paper including methods, results, sample sizes, quality scores, and conclusions. Use for literature reviews, evidence synthesis, and finding experimental details not available in abstracts alone.
Use this skill when working with Brain Imaging Data Structure (BIDS) datasets: organizing neuroscience and biomedical data (MRI, EEG, MEG, iEEG, PET, microscopy, NIRS, motion capture, EMG, MR spectroscopy, behavioral), querying BIDS layouts, validating compliance, converting DICOM to BIDS, writing metadata sidecars, or creating BIDS derivatives.
Comprehensive molecular biology toolkit. Use for sequence manipulation, file parsing (FASTA/GenBank/PDB), phylogenetics, and programmatic NCBI/PubMed access (Bio.Entrez). Best for batch processing, custom bioinformatics pipelines, BLAST automation. For quick lookups use gget; for multi-service integration use bioservices.
Unified Python interface to 40+ bioinformatics services. Use when querying multiple databases (UniProt, KEGG, ChEMBL, Reactome) in a single workflow with consistent API. Best for cross-database analysis, ID mapping across services. For quick single-database lookups use gget; for sequence/file manipulation use biopython.
End-to-end bulk RNA-seq orchestrator — takes raw FASTQ reads through QC and trimming (FastQC, fastp/Trim Galore), alignment and quantification (STAR, Salmon, featureCounts), assembles a gene-level counts matrix, then hands off to differential expression (pydeseq2), pathway/GSEA enrichment (pathway-enrichment), and publication figures (scientific-visualization). Use whenever the user has bulk RNA-seq reads or quant output and wants a complete, reproducible differential-expression workflow — e.g. "analyze my RNA-seq", "FASTQ to DESeq2", "run nf-core/rnaseq", "STAR/Salmon quantification", "build a counts matrix for DESeq2", or "go from reads to differentially expressed genes and enriched pathways". Routes between an nf-core/rnaseq (Nextflow) path and a standalone STAR/Salmon path, and covers experimental design, strandedness, and QC gates. For single-cell RNA-seq use the scanpy skill instead.
Query the CZ CELLxGENE Census programmatically for versioned public single-cell and spatial transcriptomics data. Use when you need population-scale cell metadata, gene expression slices, Census summary counts, source H5AD URIs/downloads, embeddings, spatial Census data, or reference atlas comparisons across organisms, tissues, diseases, assays, and cell types. For analyzing your own local single-cell data use scanpy, anndata, or scvi-tools.
Google quantum computing framework. Use when targeting Google Quantum AI hardware, designing noise-aware circuits, or running quantum characterization experiments. Best for Google hardware, noise modeling, and low-level circuit design. For IBM hardware use qiskit; for quantum ML with autodiff use pennylane; for physics simulations use qutip.
Comprehensive citation management for academic research. Search OpenAlex, PubMed, and Google Scholar for papers, extract accurate metadata, validate citations, and generate properly formatted BibTeX entries. This skill should be used when you need to find papers, verify citation information, convert DOIs to BibTeX, or ensure reference accuracy in scientific writing.
Prepare and validate research-only clinical decision-support evaluation, evidence-profile, cohort, survival, biomarker/model, privacy, and governance artifacts. Use for aggregate or synthetic research documentation and traceability—not patient care or live clinical operation.
Create safety-bounded draft structures and run local deterministic checks for clinical case, diagnostic, trial, safety, and aggregate research reports. Use only with synthetic, de-identified, or aggregate inputs and verified source-fact manifests; every output requires qualified review.
Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.
Run a multi-perspective Mind Council deliberation on any question, decision, or creative challenge. Use this skill whenever the user wants diverse viewpoints, needs help making a tough decision, asks for a council/panel/board discussion, wants to explore a problem from multiple angles, requests devil's advocate analysis, or says things like "what would different experts think about this", "help me think through this from all sides", "council mode", "mind council", or "deliberate on this". Also trigger when the user faces a dilemma, trade-off, or complex choice with no obvious answer.
Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clusters. Best for parallel file processing, distributed ML, integration with existing pandas code. For out-of-core analytics on single machine use vaex; for in-memory speed use polars.
Query documented public database APIs with explicit endpoints, filters, pagination, and provenance. Use when a scientific, regulatory, financial, or other database-backed fact must be retrieved reproducibly from a named source rather than inferred from general knowledge.
Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery including SMILES parsing, standardization, descriptors, fingerprints, clustering, 3D conformers, parallel processing. Returns native rdkit.Chem.Mol objects. For advanced control or custom parameters, use rdkit directly.
Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first PyTorch workflows use torchdrug; for benchmark datasets use pytdc.
Generate transcriptome-wide virtual spatial transcriptomics from H&E histology with DeepSpot-M. Use when you need spatial gene expression in log1p-CPM for 224x224 tiles at about 20x, want to query protein-coding genes by symbol instead of a fixed panel, or want to run prediction across a whole slide after tiling with histolab.
NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for ChIP-seq, RNA-seq, ATAC-seq visualization.