Overview
depmap is an open-source data skill for Claude Code and compatible agents, published by K-Dense-AI. Its author describes it as: “Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic le…”. The project has 34k stars on GitHub and is available under the MIT license. Add it to your setup with `git clone https://github.com/K-Dense-AI/scientific-agent-skills ~/.claude/skills/depmap`.
What depmap does
The Cancer Dependency Map (DepMap) project, run by the Broad Institute, systematically characterizes genetic dependencies across hundreds of cancer cell lines using genome-wide CRISPR knockout screens (DepMap CRISPR), RNA interference (RNAi), and compound sensitivity assays (PRISM). DepMap data is essential for: - Identifying which genes are essential for specific cancer types - Finding cancer-selective dependencies (therapeutic targets) - Validating oncology drug targets - Discovering synthetic lethal interactions
What’s inside
The SKILL.md for depmap is organised into these sections:
- Overview
- When to Use This Skill
- Core Concepts
- Dependency Scores
- Cell Line Annotations
- Core Capabilities
- 1. DepMap API
- 2. Gene Dependency Scores
- 3. Download-Based Analysis (Recommended for Large Queries)
- 4. Identifying Selective Dependencies
- 5. Biomarker Analysis (Gene Effect vs. Mutation)
- 6. Co-Essentiality Analysis
Installation
Add depmap to your agent with:
git clone https://github.com/K-Dense-AI/scientific-agent-skills ~/.claude/skills/depmapReview a skill’s source before installing it — skills can instruct your agent to run commands. This command comes from the skill’s public repository, which is the source of truth for setup steps. New to skills? Read how to install Claude Code skills.
Supported agents
Neither the skill nor its repository names a specific agent. It uses the SKILL.md format, which several agents can load — check the repository for any agent-specific requirements.
License
depmap is published under the MIT license.
Strengths
- Clear MIT license — safe to read and adapt within its terms
- Ships in K-Dense-AI/scientific-agent-skills, an established project with 33,821 GitHub stars
- Actively maintained — repository updated in the last 90 days
Author
Topics
Frequently asked questions
- What does depmap do?
- Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.
- How do I install depmap?
- Run git clone https://github.com/K-Dense-AI/scientific-agent-skills ~/.claude/skills/depmap in your agent, then reload your skills. Review the source at https://github.com/K-Dense-AI/scientific-agent-skills before installing.
- Is depmap free to use?
- Yes. depmap is free and open source under the MIT license, so you can read, run, and adapt it within that license's terms.
- Where does depmap come from?
- depmap ships inside K-Dense-AI/scientific-agent-skills, a repository that contains 42 catalogued skills in total. The repository's 33,821 GitHub stars apply to that whole collection, not to this skill on its own.